Intermediate Cells of the Pancreas
نویسنده
چکیده
The well known hypertrophy of the rat exocrine pancreas caused by dietary soybean trypsin inhibitor (STI) has now been shown to be accompanied by an increased prominence of acinar-/? intermediate cells and a reduction in the size of the islets of Langerhans. The acinar-/? cells are situated in the exocrine tissue surrounding the islets where the acinar cells in STI-fed rats show a greater number of zymogen granules than in acinar cells elsewhere in the pancreas or in peri-islet acinar cells of control rats. Consistent with the reduction in islet size in STI-fed rats is a lowered insulin content of the pancreas and a lowered insulin secretion following the intravenous administration of glucose. However, the release of insulin into the blood and pancreatic juice after intravenous administration of the hormone secretin is similar in both STI-fed and control rats. The results of these morphological and functional studies are discussed in relation to the possible contribution of the acinar-/? cell to the functional insulin pool.
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